Zhiwei Zhang

Zhiwei Zhang

Zhiwei Zhang

Associate Professor and
Director of Statistical Collaboratory

Office: 1427 Olmsted Hall 
Mail:1337 Olmsted Hall
University of California, Riverside
Riverside, CA 92521

Email: zhiwei.zhang@ucr.edu
Voice: 951-827-6002
Fax: 951-827-3286
Website: https://www.researchgate.net/profile/Zhiwei_Zhang6

Class Offerings:

  • STAT 255: Causal Inference (Fall 2016)
  • STAT 205: Discrete Data Analysis (Winter 2017)

  • STAT 155: Probability and Statistics in Science and Engineering (Spring 2017)


PhD in Biostatistics, University of Pittsburgh, 2003
MS in Medicinal Chemistry, Chinese Academy of Medical Sciences, 1997
BS in Applied Chemistry, Beijing Medical University, 1994


Precision medicine; causal inference; missing data; clinical trials; observational studies; likelihood paradigm; longitudinal data analysis; pooling (e.g., group testing); evaluation of diagnostic tests

Selected Publications (*corresponding author):

Liu W, Zhang Z*, Nie L, Soon G. A case study in personalized medicine: rilpivirine vs. efavirenz for treatment-naïve HIV patients. Accepted by Journal of the American Statistical Association – Applications and Case Studies.

Zhang Z, Ma S, Nie L, Soon G. A quantitative concordance measure for comparing and combining treatment selection markers. Accepted by International Journal of Biostatistics.

Liu W, Pantoja-Galicia N, Zhang B, Kotz RM, Pennello G, Zhang H, Jacob J, Zhang Z*. Generalized linear mixed models for multi-reader multi-case studies of diagnostic tests. Accepted by Statistical Methods in Medical Research.

Zhang Z, Li M, Lin M, Soon G, Greene T, Shen C 2017). Subgroup selection in adaptive signature designs of confirmatory clinical trials. Journal of the Royal Statistical Society – Series C (Applied Statistics), 66, 345-361.

Zhang Z, Cheon K (2017). Treatment comparison in randomized clinical trials with nonignorable missingness: a reverse regression approach. Statistical Methods in Medical Research, 26, 776-795.

Liu W, Zhang B, Zhang H, Zhang Z* (2017). Likelihood-based methods for evaluating principal surrogacy in augmented vaccine trials. Statistical Methods in Medical Research, 26, 984-996.

Liu W, Zhang Z*, Schroeder RJ, Ho M, Zhang B, Long C, Zhang H, Irony TZ (2016). Joint estimation of treatment and placebo effects in clinical trials with longitudinal blinding assessments. Journal of the American Statistical Association – Applications and Case Studies, 111, 538-548.

Zhang Z, Zhou J, Cao W, Zhang J (2016). Causal inference with a quantitative exposure. Statistical Methods in Medical Research, 25, 315-335.

Zhang Z, Nie L, Soon G, Hu Z (2016). New methods for treatment effect calibration, with applications to non-inferiority trials. Biometrics, 72, 20-29.

Zhang Z, Liu W, Zhang B, Tang L, Zhang J (2016). Causal inference with missing exposure information: methods and applications to an obstetric study. Statistical Methods in Medical Research, 25, 2053-2066.

Zhang Z, Qu Y, Zhang B, Nie L, Soon G (2016). Use of auxiliary covariates in estimating a biomarker-adjusted treatment effect model with clinical trial data. Statistical Methods in Medical Research, 25, 2103-2119.

Wang C, Kane R, Levenson M, Kelman J, Wernecke M, Lee J-Y, Kozlowski S, Dekmezian C, Zhang Z, Thompson A, Smith K, Wu Y-T, Wei Y, Chillarige Y, Ryan Q, Worrall C, MaCurdy TE, Graham DJ (2016). Association between changes in CMS reimbursement policy and drug labels for erythrocyte-stimulating agents with outcomes for older patients undergoing hemodialysis covered by fee-for-service Medicare. Journal of the American Medical Association – Internal Medicine, 176, 1818-1825.

Zhang Z, Wang C, Troendle JF (2015). Optimizing the order of hypotheses in serial testing of multiple endpoints in clinical trials. Statistics in Medicine, 34, 1467-1482.

Jackson JC, Albert PS*, Zhang Z (2015). A two-state mixed hidden Markov model for risky teenage driving behavior. Annals of Applied Statistics, 9, 849-865.

Zhou J, Zhang Z, Li Z, Zhang J (2015). Coarsened propensity scores and hybrid estimators for missing data and causal inference. International Statistical Review, 83, 449-471.

Gollenberg AL, Addo OY, Zhang Z, Himes JH, Lee PA, Hediger ML (2015). In utero exposure to cigarette smoking, environmental tobacco smoke and reproductive hormones in U.S. girls approaching puberty. Hormone Research in Pediatrics, 83, 36-44.

Zhang Z, Nie L, Soon G, Zhang B (2014). Sensitivity analysis in non-inferiority trials with residual inconstancy after covariate adjustment. Journal of the Royal Statistical Society – Series C (Applied Statistics), 63, 515-538.

Zhang Z. (2014). Reverse regression: a method for joint analysis of multiple endpoints in randomized clinical trials. Statistica Sinica, 24, 1753-1769.

Zhang Z, Liu C, Kim SD, Liu A (2014). Prevalence estimation subject to misclassification: the mis-substitution bias and some remedies. Statistics in Medicine, 33, 4482-4500.

Zhang Z, Nie L, Soon G, Liu A (2014). The use of covariates and random effects in evaluating predictive biomarkers under a potential outcome framework. Annals of Applied Statistics, 8, 2336-2355.

Zhang Z, Zhang B (2013). A likelihood paradigm for clinical trials (with discussion and rejoinder). Journal of Statistical Theory and Practice, 7, 157-177 (rejoinder: 196-203).

Jackson J, Albert PS, Zhang Z, Simons-Morton BG (2013). Ordinal latent variable models and their application in the study of newly licensed teenage drivers. Journal of the Royal Statistical Society – Series C (Applied Statistics), 62, 435-450.

Zhang Z, Kotz RM, Wang C, Ruan S, Ho M (2013). A causal model for joint evaluation of placebo and treatment-specific effects in clinical trials. Biometrics, 69, 318-327.

Soon G, Zhang Z, Tsong Y, Nie L* (2013). Assessing overall evidence from non-inferiority trials with shared historical data. Statistics in Medicine, 32, 2349-2363.

Kim SD, Chen Z, Zhang Z, Simons-Morton BG, Albert PS (2013). Bayesian hierarchical Poisson regression models: an application to a driving study with kinematic events. Journal of the American Statistical Association – Applications and Case Studies, 108, 494-503.

Nie L, Zhang Z*, Rubin DB, Chu J (2013). Calibration of treatment effect size through propensity score ratio reweighting, with application to clinical trials. Annals of Applied Statistics, 7, 1796-1813.

Zhang Z, Wang C, Nie L, Soon G (2013). Assessing the heterogeneity of treatment effects via potential outcomes of individual patients. Journal of the Royal Statistical Society – Series C (Applied Statistics), 62, 687-704.

Zhang Z, Albert PS, Simons-Morton B (2012). Marginal analysis of longitudinal count data in long sequences: methods and applications to a driving study. Annals of Applied Statistics, 6, 27-54.

Simons-Morton BG, Zhang Z, Jackson J, Albert PS (2012). Do elevated gravitation force events while driving predict crashes and near crashes? American Journal of Epidemiology, 175, 1075-1079.

Liu A, Liu C, Zhang Z, Albert PS (2012). Optimality of group testing in the presence of misclassification. Biometrika, 99, 245-251.

Whitcomb BW, Perkins NJ, Zhang Z, Ye A, Lyles RH (2012). Assessment of skewed exposure in case-control studies with pooling. Statistics in Medicine, 31, 2461-2472.

Zhang Z, Liu A, Lyles RH, Mukherjee B (2012). Logistic regression analysis of biomarker data subject to pooling and dichotomization. Statistics in Medicine, 31, 2473-2484.

Lyles RH, Tang L, Lin J, Zhang Z, Mukherjee B (2012). Likelihood-based methods for regression analysis with binary exposure status assessed by pooling. Statistics in Medicine, 31, 2485-2497.

Zhang Z, Chen Z, Troendle JF, Zhang J (2012). Causal inference on quantiles with an obstetric application. Biometrics, 68, 697-706.

Troendle JF, Zhang Z, Mathews ME, Guo J (2012). Methods of adjusted comparison of medians. Biometrical Journal, 54, 481-493.

Cheon K, Albert PS, Zhang Z (2012). The impact of random-effect misspecification on percentile estimation for longitudinal growth data. Statistics in Medicine, 31, 3708-3718.

Hayes L, Zhang Z, Albert PS, Zervas M, Ahn S* (2011). The timing of sonic hedgehog and gli1 expression segregates midbrain dopamine neurons. Journal of Comparative Neurology, 519, 3001-3018.

Zhang Z, Albert PS (2011). Binary regression analysis with pooled exposure measurements: A regression calibration approach. Biometrics, 67, 636-645.

Zhang Z, Addo OY, Himes JH, Hediger ML, Albert PS, Gollenberg AL, Lee PA, Louis GMB (2011). A two-part model for reference curve estimation subject to a limit of detection. Statistics in Medicine, 30, 1455-1465.

Simons-Morton BG, Ouimet MC, Zhang Z, Lee SE, Klauer SE, Wang J, Albert PS, Dingus TA (2011). Risky driving and crash rates among novice teenagers and their parents. American Journal of Public Health, 101, 2362-2367.

Simons-Morton BG, Ouimet MC, Zhang Z, Lee SE, Klauer SE, Wang J, Chen R, Albert PS, Dingus TA (2011). Naturalistic assessment of risky driving and crash/near crashes among novice teenagers: the effect of passengers. Journal of Adolescent Health, 49, 587-593.

Lee PA, Gollenberg AL, Hediger ML, Himes JH, Zhang Z, Louis GMB (2010). Luteinizing hormone, testosterone and inhibin b levels at the onset of puberty and racial/ethnic differences among boys aged 6-11 years: Analyses from NHANES III, 1988-1994. Clinical Endocrinology, 73, 744-751.

Zhang Z (2010). Profile likelihood and incomplete data. International Statistical Review, 78, 102-116.

Zhang Z (2009). Likelihood-based confidence sets for partially identified parameters. Journal of Statistical Planning and Inference, 139, 696-710.

Zhang Z (2009). Estimating a marginal causal odds ratio subject to confounding. Communications in Statistics: Theory and Methods, 38, 309-321.

Zhang Z (2009). Covariate-adjusted putative placebo analysis in active-controlled clinical trials. Statistics in Biopharmaceutical Research, 1, 279-290.

Zhang Z (2009). Interpreting statistical evidence with empirical likelihood functions.  Biometrical Journal, 51, 710-720.

Zhang Z, Kotz RM (2008). Inference and sample size calculation in the fit assessment of filtering facepiece respirators. Journal of Biopharmaceutical Statistics, 18, 713-723.

Zhang Z (2007). Estimating the current treatment effect with historical control data. JP Journal of Biostatistics, 1, 217-247.

Zhang Z, Rockette HE (2007). An EM algorithm for regression analysis with incomplete covariate information. Journal of Statistical Computation and Simulation, 77, 163-173.

Zhang Z, Rockette HE (2006). Semiparametric maximum likelihood for missing covariates in parametric regression. Annals of the Institute of Statistical Mathematics, 58, 687-706.

Zhang Z (2006).  Non-inferiority testing with a variable margin. Biometrical Journal, 48, 948-965.

Zhang Z, Rockette HE (2005). On maximum likelihood estimation in parametric regression with missing covariates. Journal of Statistical Planning and Inference, 134, 206-223.

Wang QJ, Jenkins FJ, Jacobson LP, Kingsley LA, Day RD, Zhang Z, Meng Y, Pellet PE, Kousoulas KG, Baghian A, Rinaldo CR* (2001). Primary human herpesvirus 8 infection generates a broadly specific CD8+ T cell response to viral lytic proteins without a specific illness or immunosuppression. Blood, 97, 2366-73.


Merit Assistantship (1997-1998), University of North Carolina at Chapel Hill

Problem Corner Winner (2000), Chance magazine

Best Doctoral Dissertation of the Year (2004), Department of Biostatistics, University of Pittsburgh

Student of the Year (2004), Pittsburgh Chapter, American Statistical Association

Scientific Excellence Award (2008, as Outstanding Junior Investigator), FDA

Scientific Excellence Award (2015, for Excellence in Analytical Science), FDA

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